Nasalox Nasal 0.00025

৳ 40.00

General Pharmaceuticals Ltd.

Oxymetazoline Hydrochloride (Nasal)

Indications

Oxymetazoline Hydrochloride is applied topically to relieve nasal congestion associated with acute or chronic rhinitis, common cold, sinusitis, and hay fever or other allergies. It is also used as nasal decongestant in otitis media.

Therapeutic Class

Nasal Anti-histamine preparations, Nasal Decongestants & Other Nasal Preparations

Pharmacology

Oxymetazoline is a direct-acting sympathomimetic which has vasoconstrictor effect on mucosal blood vessels when applied topically and in turn reduces oedema of the nasal mucosa.

Dosage

Adults and children 6 years of age and older: 2-3 drops or sprays in each nostril twice daily for 3-5 days.

Children of age 2-6 years: 2-3 drops in each nostril twice daily for 3-5 days. Sprays are generally unsuitable for young children because of the small size of their nostrils. The drug is not recommended in children under the age of 2 years.

Administration

The nasal spray can be used with the patient in the upright position. Sprays are generally unsuitable for young children because of the small size of their nostril. A treatment course should not normally exceed three to five days, and on no account should it be continued for longer than two weeks because of the risk of developing “rhinitis medicamentosa”.

Interaction

Monoamine oxidase inhibitors (MAOIs): Concomitant use of oxymetazoline and MAOI can result in  hypertensive reaction.

Tricyclic antidepressants (TCAs): TCAs may increase the effects of oxymetazoline on blood pressure.

Contraindications

Contraindicated in patients hypersensitive to Oxymetazoine Hydrochloride.

Side Effects

Transient burning, dryness of the nasal mucosa, sneezing, Nervousness, dizziness, headache, Hypertension, palpitation or reflex bradycardia.

Pregnancy & Lactation

Pregnancy: Safe use of oxymetazoline during pregnancy has not been established; it should be avoided by pregnant women.

Nursing Mother: It is not known whether oxymetazoline is secreted in human breast milk; caution is advised.

Precautions

  • Prolonged use may result in rebound congestion.
  • Since oxymetazoline has systemic adverse effects, it should be used with caution in patients with
  • Hypertension, cardiovascular disease or hyperthyroidism or in those receiving MAO inhibitors.

Overdose Effects

Following a proper application, systemic action is unlikely. If, however, some of the drops are swallowed, systemic effect can be produced. Symptoms include rapid, irregular heartbeat, headache, dizziness, increased sweating, nervousness. Such symptoms are more likely to be seen in young children.

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