Bronchodilator, Chronic obstructive pulmonary disease (COPD)

Short-acting selective β2-adrenoceptor stimulants

Tulobuterol is a direct-acting sympathomimetic with selective action on β2-receptors. It is available orally, as a inhaler and as a transdermal patch. It is given as the hydrochloride by mouth and the base as transdermal formulation and inhalation.

Bronchodilator:

• Adult: Initially, 1-2 mg bid, increase to 2 mg tid if necessary.
• Child: 1-6 yr: 0.25-0.5 mg bid, 6-10 yr: 0.5-1 mg bid, 10-14 yr: 1-1.5 mg bid.

Increased risk of arrhythmia with digoxin. Hypokalaemia with concomitant admin of xanthines, corticosteroids and diuretics.

Phaeochromocytoma.

Fine tremor of skeletal muscle, palpitations, muscle cramps, tachycardia, nervous tension, headache, peripheral vasodilatation, hypersensitivity reactions.

Pregnancy category not classified

Hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension and DM.