Use for the improvement of thinking, learning and memory in people suffering from Alzheimer’s disease, dementia, head trauma, Parkinson’s disease and glaucoma. Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.
CNS stimulant drugs
Citicoline is a naturally occurring, water-soluble biological compound that is essential intermediate for the synthesis of phosphatidylcholine, a major constituent of the gray matter of brain tissue. Citicoline promotes brain metabolism by enhancing the synthesis of acetylcholine and restoring phospholipid content in the brain. It also elevates brain oxygen consumption and improves brain metabolism. Citicoline seems to increase a brain chemical called phosphatidylcholine. This brain chemical is important for brain function. Citicoline might also decrease brain tissue damage when the brain is injured.
Disturbance of Consciousness
: Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.
Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once daily for 2 consecutive weeks or as prescribed by the physician.
Zynapse potentiates the effects of L-dopa.
Hypersensitivity to citicoline sodium or to any of the excipients of Citicoline.
Rash, Insomnia, headache, dizziness, convulsion, Nausea, anorexia, Abnormal liver function in laboratorium measurement, Diplopia, Flushing, transient blood pressure changes or malaise.
There is inadequate evidence of safe use of citicoline in human pregnancy. Citicoline should be used in pregnancy and lactation only if the potential benefits justify the potential risks.
In acute and emergency condition, citicoline should be administered. In conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continue, avoid giving high-dose citicoline (>500 mg concomitantly), since it may exaggerate blood flow in brain. In case small dose of citicoline (100-500 mg 2-3 times daily) may be needed.
Precaution should be given in patients with hypersensitivity. For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection recommended within 2 weeks after apoplectic stroke.
Use in pregnancy: Citicoline is avoided in pregnancy.
Use in lactation: Citicoline is avoided by nursing mothers.
Store below 25° C