Clavuran Tablet 200 mg+125 mg

৳ 35.15

Drug International Limited

Cefpodoxime + Clavulanic Acid

Indications

Cefpodoxime & Clavulanic Acid is indicated in-

Upper respiratory tract infection: Pharyngitis, Tonsillitis.
Lower respiratory tract infection: Acute exacerbations of chronic bronchitis, Acute community acquired pneumonia.
Skin and Soft Tissue Infections.
Urinary tract infection: Cystitis, Uncomplicated urinary tract infections.
Enteric fever.
General gonorrhea and rectal gonococcal infections.

Therapeutic Class

Third generation Cephalosporins

Pharmacology

Cefpodoxime-Clavulanic acid is a combination of two drugs and is effective against multiple infection types. Clavulanic acid component protects degeneration of cefpodoxime in presence of beta-lactamase enzymes and increases the antibiotic spectrum.

Cefpodoxime-Clavulanic acid preparation prevents the resistance to Cefpodoxime that may increase with continuous usage of the drug. It has shown effectiveness against multiple Gram-positive and Gram-negative bacteria and is generally well tolerated.

Dosage & Administration

Pharyngitis or tonsillitis: 100 mg 12 hourly for 5 to 10 days
Uncomplicated urinary tract infections: 100 mg 12 hourly for 7 days
Complicated urinary tract infections: 200 mg 12 hourly for7 days
Acute community acquired pneumonia: 200 mg 12 hourly for 14 days
Acute bacterial exacerbations of chronic bronchitis: 200 mg 12 hourly for 10 days
Uncomplicated gonorrhea and rectal gonococcal infections: single dose
Skin and skin structure infections: 200-400 mg 12 hourly for 7 to 14 days
Acute maxillary sinusitis: 200 mg 12 hourly for 10 days
Enteric fever: 200 mg 12 hourly for 7 to 14 days

Interaction

Probenecid: Renal excretion of Cefpodoxime proxetil was inhibited by Probenecid and resulted in an approximately 31% increase in AUC.

Nephrotoxic drugs: Close monitoring of renal function is advised when Cefpodoxime proxetil is administered concomitantly with compounds of known nephrotoxic potential.

Contraindications

It is contraindicated in patients with a known allergy to cefpodoxime and clavulanic acid or to the cephalosporin group of antibiotics.

Side Effects

It has very few side effects. The side effects include diarrhoea, nausea, skin and vaginal fungal infection, vulvo-vaginal infections, abdominal pain and headache.

Pregnancy & Lactation

Cefpodoxime is pregnancy category B and Clavulanic acid is pregnancy category B.

Precautions

Cross hypersensitivity in penicillin sensitive patients, leading to serious acute hypersensitivity reactions may need treatment with epinephrine along with other emergency measures such as intravenous fluids, oxygen, airway management and intravenous antihistamine, as clinically indicated.

Use in Special Population

Patients with renal dysfunction: For patients with severe renal impairment (< 30 ml/min creatinine clearance), the dosing intervals should be increased to 24 hourly. In patients maintained on hemodialysis, the dose frequency should be 3 times/week after hemodialysis.

Patients with cirrhosis: Cefpodoxime pharmacokinetics in cirrhotic patients (with or without ascites) is similar to those in healthy subjects. Dose adjustment is not necessary in this population.

Storage Conditions

Store in cool and dry place. Keep away from children.

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