Treatment of progesterone deficiencies such as:
- Treatment of dysmenorrhoea
- Treatment of endometriosis
- Treatment of secondary amenorrhoea
- Treatment of irregular cycles
- Treatment of dysfunctional uterine bleeding
- Treatment of pre-menstrual syndrom
- Treatment of threatened and habitual abortion, associated with proven progesterone deficiency
- Treatment of infertility due to luteal insufficiency
Dosage & Administration
Recurrent miscarriage: 10 mg bid given cyclically until conception, then continuously until wk 20 of pregnancy, after which dose may be gradually reduced.
Infertility: 10 mg bid.
Menstrual disorders: 10 mg bid in a cyclical regimen.
Endometriosis: 10 mg bid-tid cyclically or continuously.
Threatened miscarriage: Initially, 40 mg followed by 10 mg or more every 8 hr, continued for a wk after symptoms are relieved. Reduce dose gradually after that unless symptoms return.
Endometrial protection during menopausal hormonal replacement therapy: 10 mg 1-2 times daily in a cyclical regimen or 5 mg daily.
Pregnancy & Lactation
From spontaneous surveillance systems to date, there is no evidence that dydrogesterone can not be used during pregnancy.
Dydrogesterone is excreted in the milk of nursing mothers. A risk to the suckling child cannot be excluded. Dydrogesterone should not be used during breast-feeding.
There is no evidence that dydrogesterone decreases fertility at therapeutic dose.