- Severe infections, such as septicemia, bacteremia and infections in immunosuppressed neutropenic patients with hematological malignancies
- Lower respiratory infections including pneumonia
- Severe urinary tract infections including pyelonephritis
- Skin and soft tissue infections
- Bone and joint infections
- Infections in immunocompromised patients
- Other infections
Dosage & Administration
Elderly: There are no special precautions for its use in the elderly provided dosage is adjusted accordingly to renal function.
Cefpirome is administered only through the parenteral route. The dosage is dependent upon the severity and site of infection, the susceptibility of the infecting microorganisms and age, weight and renal function of the patient. The drug is administered through intravenous injection or infusion. The following dosages are recommended for moderate to severe infections in adult patients with normal renal function:
- Complicated upper & lower urinary tract infections: 1 gm 12 hourly. Total daily dose not more then 2 gm
- Skin & soft tissue infections: 1 gm 12 hourly. Total daily dose not more then 2 gm
- Lower respiratory tract infections: 1 to 2 gm 12 hourly. Total daily dose not more then 2 to 4 gm
- Bacteraemia or septicaemia and severe infections: 2 gm 12 hourly. Total daily dose not more then 4 gm
- Infections in neutropenic patients: 2 gm 12 hourly. Total daily dose not more then 4 gm
Dose reduction is necessary in patients with markedly reduced renal function. After an initial dose of 0.5 -2 gm to establish a high serum concentration, the dose should be reduced by 50% for clearances of 49-21 ml/min or 75% for clearances of 20 ml/min. In end-stage renal disease, a supplementary dose equal to 50% of the recommended daily dose should be administered after each hemodialysis
Pregnancy & Lactation
Duration of Treatment
Step 1: Add recommended volume of solvent slowly. Remove the syringe needle.
Step 2: Gently shake the vial to dissolve the powder. Carbon dioxide is released & a clear solution will be obtained.
Step 3: Now insert the needle in the free space of the reconstituted vial & withdraw the pressurized air from the free space.
Step 4: Finally withdraw the solution from the vial by syringe.