Ivera Tablet 12 mg

৳ 30.00

Beximco Pharmaceuticals Ltd.

Category:

Ivermectin (Oral)

Indications

Strongyloidiasis of the intestinal tract: Ivermectin is indicated for the treatment of intestinal (i.e., nondisseminated) strongyloidiasis due to the nematode parasite Strongyloides stercoralis.

This indication is based on clinical studies of both comparative and open-label designs, in which 64-100% of infected patients were cured following a single 200-mcg/kg dose of ivermectin.

Onchocerciasis: Ivermectin is indicated for the treatment of onchocerciasis due to the nematode parasite Onchocerca volvulus.

This indication is based on randomized, double-blind, placebo-controlled and comparative studies conducted in 1427 patients in onchocerciasis-endemic areas of West Africa. The comparative studies used diethylcarbamazine citrate (DEC-C).

Therapeutic Class

Anti-helminthic

Pharmacology

Ivermectin selectively binds and with high affinity to glutamate-gated chloride ion channels, which occur in invertebrate nerve and muscle cells leading to an increase in the permeability of cell membranes to chloride ions with hyperpolarization of the nerve or muscle cell and, ultimately, death of the parasite.

Dosage

Strongyloidiasis: A single oral dose designed to provide approximately 200 mcg of Ivermectin / kg of body weight on an empty stomach with water.

Dosage Guidelines for Ivermectin for Strongyloidiasis:

  • Body Weight (kg) 15-24: Dose 3 mg/kg
  • Body Weight (kg) 25-35: Dose 6 mg/kg
  • Body Weight (kg) 36-50: Dose 9 mg/kg
  • Body Weight (kg) 51-65: Dose 12 mg/kg
  • Body Weight (kg) 66-79: Dose 15 mg/kg
  • Body Weight (kg) >80: Dose 200 mcg/kg

Onchocerciasis: The recommended dosage of Ivermectin is a single oral dose designed to provide approximately 150 mcg of Ivermectin per kg of body weight on an empty stomach with water, the most commonly used dose interval is 12 months. For the treatment of individual patients, retreatment may be considered at intervals as short as 3 months.

Dosage Guidelines for Ivermectin for Onchocerciasis:

  • Body Weight (kg) 15-25: Dose 3 mg/kg
  • Body Weight (kg) 26-44: Dose 6 mg/kg
  • Body Weight (kg) 45-64: Dose 9 mg/kg
  • Body Weight (kg) 65-84: Dose 12 mg/kg
  • Body Weight (kg) >85: Dose 150 mcg/kg

Administration

Should be taken on an empty stomach.

Interaction

Bioavailability may be increased by alcohol, levamisole.

Contraindications

Hypersensitive to any component of this product.

Side Effects

The common side effects are fatigue, abdominal pain, anorexia constipation, diarrhea, nausea, vomiting , dizziness, somnolence, vertigo, tremor, pruritus, urticaria, synovitis lymph node enlargement (axillary ,cervical, inguinal), skin involvement including edema, papular and pustular or frank urticarial rash , and fever, eyelid edema, anterior uveitis, conjunctivitis, limbitis, keratitis, and chorioretinitis or choroiditis.

Pregnancy & Lactation

Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.

Precautions

Concurrent Loa loa infection, impaired blood-brain barrier function due to infection.

Storage Conditions

Store below 30°C.

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