Stimulation of gut motility in-
- Non-ulcer dyspepsia
- Oesophageal reflux, reflux oesophagitis and gastritis
- Diabetic gastroparesis
- Functional dyspepsia
- Speeding barium transit in follow through radiological studies
Prevention and symptomatic relief of acute nausea and vomiting from any cause including cytotoxic therapy, radiotherapy and antiparkinsonism therapy
In the prophylactic treatment of migraine
Motility Stimulants, Motility stimulants/Dopamine antagonist, Prokinetic drugs
Domperidone is dopamine receptor (D2) antagonist which selectively inhibits dopamine at the D2 receptor. It acts principally at receptors in the chemoreceptor trigger zone (CTZ) and also at receptors in the stomach.
10 – 20 mg every 4 – 8 hours dailyChildren:
0.2 – 0.4 mg/kg every 4 – 8 hours daily.
Domperidone tablet and suspension should be taken 15 – 30 minutes before a meal. For acute nausea and vomiting, maximum period of treatment is 12 weeks.
Domperidone may reduce the hypoprolactinaemic effect of bromocriptine. Anti-muscarinics and opioid analgesics may antagonize the action of Domperidone on gastrointestinal function.
Domperidone is contraindicated to the patients who have hypersensitivity to this drug and in case of neonates.
Domperidone may produce hyperprolactinemia which may cause galactorrhea & breast enlargement, soreness and reduced libido. It may rarely cause dry mouth, thirst, headache, nervousness, drowsiness, diarrhea, skin rash and itching.
Use in pregnancy:
The safety of this drug has not been established for pregnant women. So it is not recommended during pregnancy.
Use in lactation: Domperidone may precipitate galactorrhea and improve postnatal lactation, which is secreted in breast milk but in very small quantities insufficient to be considered harmful.
Domperidone should be used with absolute caution in case of children because there may be an increased risk of extra-pyramidal reactions in young children because of an incompletely developed blood brain barrier.
Overdose has been reported primarily in infants and children. Symptoms of overdosage may include disorientation, somnolence and extrapyramidal reactions. There is no specific antidote to domperidone, but in the event of overdose, the administration of activated charcoal may be useful. Anticholinergics, antiparkinson drugs may be useful in controlling extrapyramidal reactions. The patient should be observed closely and supportive measures employed.
Store in a cool dry place protected from light. Keep out of reach of children.