- Infections of the skin, hair and nails by dermatophytes and/or yeasts (dermatomycosis, onychomycosis, perionyxis, pityriasis versicolor, chronic mucocutaneous candidiasis etc.) especially when topical treatment is difficult or not very effective, owing to involvement of large skin surfaces or to lesions affecting deeper dermal layers, nails and hairs
- Yeast infection of the mouth (oral thrush, perleche) and the gastrointestinal tract
- Vaginal candidiasis, especially chronic recurrent cases or cases responding poorly to topcial treatment
- Systemic mycotic infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis, coccidioidomycosis etc.
Maintenance treatment to prevent recurrence in systemic mycotic infections and in chronic mucocutaneous candidiasis.
Prophylactic treatment to prevent mycotic infection in patients with reduced host defenses, e.g., patients with cancer, organ transplant and burns.
Dosage & Administration
- Adult: 200 mg once daily; may increase to 400 mg once daily if clinical response is insufficient. Continue treatment until symptoms have cleared and cultures have become negative.
- Child: ≥2 yr 3.3-6.6 mg/kg once daily. Treatment duration: 1-2 wk for candidiasis; at least 4 wk in recalcitrant dermatophyte infections and up to 6 mth for other systemic mycoses.
- Elderly: No dosage adjustment needed.
Pityriasis versicolor, Skin fungal infections:
- As 2% cream: Apply 1-2 times daily to cover affected and surrounding area until at least a few days after disappearance of symptoms.
- As 2% shampoo: Apply on scalp once daily for up to 5 days. For prophylaxis: As 2% shampoo, use once daily for a max of 3 days before exposure to sunlight.
- As 2% foam: Apply to the affected area bid for 4 wk.
- As 1 or 2% shampoo: Apply on the scalp twice wkly for 2-4 wk. For prophylaxis: As 2% shampoo, use once every 1-2 wk.
Pregnancy & Lactation
Use in Special Population
Hepatic Impairment: Oral: Contraindicated.
Duration of Treatment
- Pityriasis versicolor: 1 to 6 weeks
- Dermatomycoses: 2 to 8 weeks
- Onychomycoses: 1 to 12 months
- Mycoses of hair and scalp: 1 to 2 months
- Chronic mucocutaneous candidiasis : 1 to 12 months
- Oral mycoses: 5 to 10 days
- Systemic candidiasis: 1 to 2 months
- and other systemic mycosis: 1 month to 2 years