Pase Tablet 0.5 mg

৳ 6.00

Opsonin Pharma Ltd.




Clonazepam (Oral) is indicated in:

  • Anxiety disorders (Generalized, Phobic & Panic disorders)
  • Insomnia and sleep disturbances
  • Labile arterial hypertension
  • Peri and Post menopausal anxiety (Anxiety in middle aged women)
  • Burning Mouth Syndrome
  • Peri and Post menopausal anxiety (Anxiety in middle aged women)
  • Postoperative anxiety disorder
  • Post traumatic stress disorder
  • Anxiety in cancer patient (palliative treatment)
  • Tension Headache
  • Restless legs syndrome (RLS) or Wittmaack–Ekbom syndrome
  • Nocturnal myoclonus
  • Tourette’s syndrome
  • Bipolar affective disorder
  • Resistant depression
  • Drug-induced dyskinesia
  • Choreiform movement
  • Fulgurant pain
  • Trigeminal neuralgia
  • Epilespsy

Clonazepam (Injection) is indicated in:

  • Epilepsy
  • Status epilepticus
  • Myoclonic seizure
  • Typical and atypical absences (Lennox-Gastaut syndrome)
  • Infantile spasm
  • Tonic-clonic seizure
  • Partial seizure
  • Absence seizure
  • Focal seizure

Therapeutic Class

Adjunct anti-epileptic drugs, Benzodiazepine hypnotics


Clonazepam reduces the nerve transmission in the motor cortex which suppresses the spike and wave discharge in absence seizures. Its mechanism is believed to be related to its ability to enhance the activity of GABA. Clinically, it improves focal epilepsy and generalised seizures.

Dosage & Administration

Dosage must be determined in each patient according to clinical response and tolerance.


Children: The initial dose for infants and children (up to 10 years of age or 30 kg of body weight) should be between 0.01 and 0.03 mg/kg/day and should not exceed 0.05 mg/kg/day given in two or three divided doses. Dosage should be increased by not more than 0.25 to 0.50 mg every third day until a maintenance dose of 0.1 to 0.2 mg/kg of body weight has been reached, unless seizures are controlled or side effects preclude further increase. Whenever possible, the daily dose should be divided into three equal doses. If doses are not equally divided, the larger dose should be given before retiring.

Adults: 1 mg (elderly 500 micrograms) initially at night for 4 nights, increased according to response over 2-4 weeks to usual maintenance dose of 4-8 mg usually at night (may be given in 3-4 divided doses if necessary). Dosage may be increased in increments of 0.5 to 1 mg every three days until seizures are adequately controlled. A recommended maintenance dose for adults is 8 to 10 mg/day in three divided doses. Dosages in excess of 20 mg/day should be administered with caution.The use of multiple anticonvulsants may result in an increase of depressant adverse effects.This should be borne in mind whenever Clonazepam is added to an already existing anticonvulsant regimen.


Infants and children: half of a vial (0.5 mg) by slow IV injection or by IV infusion.

Adults: 1 vial (1 mg) by slow IV injection or by IV infusion. This dose can be repeated as required (1-4 mg are usually sufficient to reverse the status). In adults, the rate of injection must not exceed 0.25 – 0.5 mg per minute (0.5-1.0 ml of the prepared solution) and a total dose of 10 mg should not be exceeded.

Slow intravenous injection: The contents of the vial must be diluted with 1 ml of water for injection prior to administration so as to avoid local irritation of the veins. The injection solution should be prepared immediately before use. IV injection should be administered slowly with continuous monitoring of EEG, respiration and blood pressure.

Intravenous infusion: Clonazepam (the vial) can be diluted for infusion in a ratio of 1 vial (1 mg) to at least 85 ml diluting media. The diluting media can be any of the following: sodium chloride 0.9%; sodium chloride 0.45% + glucose 2.5%; glucose 5% or glucose 10%. These mixtures are stable for 24 hours at room temperature. Infusion bags other than PVC should be used for infusing Clonazepam. If PVC infusion bags are used then the mixture should be infused immediately or within 4 hours. The infusion time should not exceed 8 hours. Do not prepare Clonazepam infusions using sodium bicarbonate solution, as precipitation of the solution may occur.

Intramuscular injection: The IM route should be used only in exceptional cases or if IV administration is not feasible.


Interactions have been reported between some benzodiazepines and other anticonvulsants, with changes in the serum concentration of the benzodiazepine or anticonvulsant.


Clonazepam should not be used in patients with a history of sensitivity to benzodiazepine, nor in patients with clinical or biochemical evidence of significant liver disease. It may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in acute narrow angle glaucoma.

Side Effects

The most frequently occurring adverse reactions to clonazepam are referable to CNS depression, drowsiness, ataxia. In some cases, these may diminish with time. Behaviour problems and salivation have been noted.

Pregnancy & Lactation

Pregnancy category is C. The use of clonazepam during pregnancy or lactation should be avoided. Clonazepam is excreted into the breast milk and should therefore be avoided in breast-feeding mothers.


Although simultaneous administration of several anticonvulsants may be considered with clonazepam, such combined therapy may result in an increase of central depressant adverse effects. When used in patients in whom several different types of seizures co-exist, clonazepam may increase the incidence or precipitate the onset of generalized tonic-clonic seizures (grand mal).

Overdose Effects

The cardinal manifestations of overdosage are drowsiness and confusion, reduced reflexes and coma. There are minimal effects on respiration, pulse and blood pressure, unless the overdosage is extreme.

Storage Conditions

Store at 25°C.


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